Katsumi Higaki Selected Research

Carrier Proteins (Binding Protein)

11/2011	Impairment of ubiquitin-proteasome system by E334K cMyBPC modifies channel proteins, leading to electrophysiological dysfunction.
12/2008	Ubiquitin-proteasome system impairment caused by a missense cardiac myosin-binding protein C mutation and associated with cardiac dysfunction in hypertrophic cardiomyopathy.

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Katsumi Higaki Research Topics

Disease

18	Type C Niemann-Pick Disease (Niemann Pick Disease, Type C) 01/2023 - 06/2004
12	Gaucher Disease (Gaucher's Disease) 01/2019 - 08/2004
8	Lysosomal Storage Diseases (Lysosomal Storage Disease) 03/2019 - 12/2003
7	GM1 Gangliosidosis (Gangliosidosis GM1) 11/2020 - 12/2003
6	Mucopolysaccharidosis IV (Morquio Syndrome) 01/2017 - 12/2003
5	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2023 - 02/2004
4	Graves Disease (Basedow Disease) 06/2019 - 05/2014
3	Ototoxicity 01/2023 - 01/2021
3	Long QT Syndrome 10/2016 - 02/2011
3	Neurologic Manifestations (Neurological Manifestations) 03/2016 - 09/2007
3	Neoplasms (Cancer) 09/2011 - 05/2007
2	Long Qt Syndrome 2 11/2016 - 12/2013
2	Neuraminidase deficiency with beta-galactosidase deficiency 02/2016 - 10/2008
2	Fabry Disease (Fabry's Disease) 09/2015 - 07/2014
2	Hyperthyroidism 01/2015 - 05/2014
2	Sphingolipidoses (Sphingolipidosis) 04/2013 - 08/2004
2	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 11/2011 - 12/2008
2	Mucolipidoses (Sialidosis) 10/2011 - 12/2009
2	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 02/2010 - 02/2009
2	Tuberous Sclerosis (Bourneville's Disease) 09/2007 - 05/2007
2	Neuroblastoma 02/2007 - 11/2005
1	Tay-Sachs Disease 12/2022
1	Hearing Loss (Hearing Impairment) 11/2022
1	Atrial Remodeling 07/2022
1	Mitochondrial Diseases (Mitochondrial Disease) 04/2022
1	Melanoma (Melanoma, Malignant) 01/2021
1	Pain (Aches) 11/2020
1	Niemann-Pick Diseases (Niemann Pick Disease) 09/2020
1	Gout 07/2020
1	Hyperuricemia 07/2020
1	Rare Diseases (Rare Disease) 01/2020
1	Infections 01/2020
1	Virus Diseases (Viral Diseases) 01/2020
1	COVID-19 01/2020
1	Hepatomegaly 03/2019
1	Mannosidase Deficiency Diseases (Mannosidosis) 01/2019
1	Parkinson Disease (Parkinson's Disease) 01/2019
1	Immunoglobulin G4-Related Disease 10/2018
1	Weight Loss (Weight Reduction) 01/2017
1	Lipidoses 01/2017
1	Body Weight (Weight, Body) 01/2017
1	Disease Progression 01/2017

Drug/Important Bio-Agent (IBA)

11	CholesterolIBA 01/2023 - 02/2004
9	Proteins (Proteins, Gene)FDA Link 04/2022 - 10/2008
9	Glucosylceramidase (Glucocerebrosidase)IBA 01/2018 - 11/2009
7	GalactosidasesIBA 01/2017 - 08/2011
6	CyclodextrinsIBA 01/2023 - 01/2014
6	EnzymesIBA 12/2022 - 10/2011
5	LipidsIBA 01/2020 - 06/2004
5	AcidsIBA 04/2014 - 11/2010
4	GlucosidasesIBA 04/2014 - 11/2010
3	Uric Acid (Urate)IBA 07/2022 - 08/2015
3	SphingolipidsIBA 01/2020 - 02/2004
3	Long-Acting Thyroid Stimulator (LATS)IBA 10/2018 - 05/2014
3	Ambroxol (Mucosolvan)IBA 03/2016 - 04/2013
3	beta-Galactosidase (Lactaid)IBA 10/2008 - 09/2006
3	N-octyl-beta-valienamineIBA 09/2006 - 12/2003
2	Biomarkers (Surrogate Marker)IBA 01/2022 - 01/2021
2	Mutant Proteins (Protein, Mutant)IBA 10/2016 - 09/2013
2	Cathepsin AIBA 02/2016 - 10/2008
2	Neuraminidase (Sialidase)IBA 02/2016 - 10/2008
2	UbiquitinIBA 09/2015 - 12/2008
2	Proteasome Endopeptidase Complex (Proteasome)IBA 09/2015 - 12/2008
2	Phosphotransferases (Kinase)IBA 03/2015 - 10/2011
2	GlycosidesIBA 01/2015 - 08/2012
2	migalastatIBA 07/2014 - 03/2013
2	Cardiac MyosinsIBA 11/2011 - 12/2008
2	Carrier Proteins (Binding Protein)IBA 11/2011 - 12/2008
2	DystrophinIBA 02/2010 - 02/2009
2	Tuberous Sclerosis Complex 1 ProteinIBA 09/2007 - 05/2007
2	trans-sodium crocetinate (crocetin)IBA 09/2007 - 05/2007
1	OligosaccharidesIBA 01/2023
1	Hexosaminidases (Hexosaminidase)IBA 12/2022
1	Hexosaminidase A (Hex A)IBA 12/2022
1	Protons (Proton)IBA 11/2022
1	InflammasomesIBA 07/2022
1	Hormones (Hormone)IBA 04/2022
1	SteroidsIBA 04/2022
1	Therapeutic UsesIBA 01/2021
1	Glycoproteins (Glycoprotein)IBA 01/2021
1	IgA receptor (protein B)IBA 01/2021
1	CytokinesIBA 11/2020
1	sphingosine phosphorylcholineIBA 09/2020
1	Phosphorylcholine (Phosphocholine)IBA 09/2020
1	Serine (L-Serine)FDA Link 09/2020
1	Estradiol (Delestrogen)FDA LinkGeneric 06/2019
1	alpha-Mannosidase (LAMAN)IBA 01/2019
1	alpha-SynucleinIBA 01/2019
1	MannosidasesIBA 01/2019
1	AntibodiesIBA 10/2018
1	Epstein-Barr virus encoded RNA 1IBA 10/2018
1	Immunoglobulin G (IgG)IBA 10/2018
1	RNA IIBA 10/2018
1	(5aR)-5a-C-pentyl-4-epi-isofagomineIBA 01/2017
1	isofagomineIBA 01/2017
1	Histone Deacetylase InhibitorsIBA 01/2017
1	NucleotidesIBA 01/2017
1	Vorinostat FDA Link 01/2017

Therapy/Procedure

13	Therapeutics 11/2020 - 12/2003
1	Enzyme Replacement Therapy 11/2020